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51st ERA-EDTA CONGRESS

 

31 May - 3 June 2014 AMSTERDAM
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Discussion forum - 51st ERA-EDTA CONGRESS
    Topic - K) Clinical Nephrology, primary and secondary glomerulonephritis.

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Poster: 325
Visits: 29
Title: THE DOUBLE POSITIVE DISEASE: A PARTICULARLY SEVERE FORM OF SYSTEMIC VASCULITIS.
Authors: Maeva Clerte ,
Centre: Hopital Européen Georges Pompidou

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THE DOUBLE POSITIVE DISEASE: A PARTICULARLY SEVERE FORM OF SYSTEMIC VASCULITIS.

Maeva Clerte
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Subspeciality
Reg: 5/19/2014 7:43:00 AM
Comment# 1
The rapidly progressive glomerulonephritis (RPGN) syndrome is characterized by an acute renal failure with glomerular proteinuria and hematuria. Extra-renal symptoms are frequent, depending on etiology. On renal pathology, RPGN is characterized by the presence of extracapillary proliferation, forming glomerular crescents. Immunofluorescence results are specific of the etiology. Classicaly, there are three types of RPGN : Immune-complex deposit-driven GN, such as in systemic lupus erythematosus, post-infective glomerulonephritis or IgA nephropathyGoodpasture syndrome with linear deposits of anti-glomerular basement membrane (anti-GBM) antibody.Pauci-immune vasculitis associated with ANCA antibody. No immune deposits are detected. The double positive disease is characterized by the presence of both ANCA and anti-GBM. This type of vasculitis is rare, not well described and there is no consensual treatment.

Comment added on 5/19/2014 7:44:00 AM 
     
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